Slot: targetProposition

The proposition against which the evidence items were evaluated, in determining the overall strength and direction of evidence they provide (as captured in the Evidence Line)

URI: vaspec:EvidenceLine_targetProposition

Domain and Range

EvidenceLine → _0..1 Proposition

Parents

• is_a: targetProposition

Children

Used by

• EvidenceLine

Other properties

Comments:		An example based on the ACMG Guidelines for germline variant pathogenicity interpretation: consider a curator assessing the evidence provided by population frequency data for a specific variant based on the ACMG criteria. In order to assign a strength (e.g. moderate, strong) and direction (PM2 or BS1) to this data as evidence, there must be some 'target proposition' toward which the evidence is assessed. If the PM2 criteria is deemed 'met', this indicates that the population frequency evidence supports with moderate strength the target proposition that the variant is pathogenic for the disease of interest.