Skip to content

Class: Statement

An information entity expressing a declarative sentence that is either true or false.

URI: vacoreim:Statement

classDiagram class Statement InformationEntity <|-- Statement Statement : conclusion Statement --|> Coding : conclusion Statement : confidenceDirection Statement --|> Coding : confidenceDirection Statement : confidenceLevel Statement --|> Coding : confidenceLevel Statement : confidenceScore Statement --|> DataItem : confidenceScore Statement : contributions Statement --|> Contribution : contributions Statement : dateAuthored Statement : derivedFrom Statement --|> InformationEntity : derivedFrom Statement : description Statement : evidenceDirection Statement --|> Coding : evidenceDirection Statement : evidenceLevel Statement --|> Coding : evidenceLevel Statement : evidenceScore Statement --|> DataItem : evidenceScore Statement : extensions Statement --|> Extension : extensions Statement : hasEvidence Statement --|> InformationEntity : hasEvidence Statement : hasEvidenceLines Statement --|> EvidenceLine : hasEvidenceLines Statement : hasEvidenceOfTypes Statement --|> Coding : hasEvidenceOfTypes Statement : id Statement : identifiers Statement : label Statement : proposition Statement --|> Proposition : proposition Statement : recordMetadata Statement --|> RecordMetadata : recordMetadata Statement : reportedIn Statement --|> Document : reportedIn Statement : specifiedBy Statement --|> Method : specifiedBy Statement : statementText Statement : subtype Statement --|> Coding : subtype Statement : type Statement : urls Statement : xrefs

Inheritance

Slots

Name Cardinality and Range Description Inheritance
subtype 0..1
Coding		 A specific type of statement the Statement object represents (e.g. a 'Variant Pathogenicity Statement', or 'Therapeutic Response Evidence Level Statement') direct
statementText 0..1
String		 A natural-language expression of what the Statement asserts to be true. direct
proposition 0..1
Proposition		 A possible fact (Proposition) that the Statement is about. A Statement may say any or all of the following about its Proposition: (1) simply report its as being true; (2) describe the author's degree of confidence in the its truth; (3) report the author's assessment of the level and direction of evidence backing it. direct
confidenceDirection 0..1
Coding		 A term indicating whether the confidenceLevel and/or confidenceScore values reflect confidence that the statement's proposition is true or false. direct
confidenceLevel 0..1
Coding		 A term describing the asserting agent's level of confidence about the Statement's proposition (i.e. how confident they are that it is true or false). direct
confidenceScore 0..1
DataItem		 A quantitative score the asserting agent's level of confidence about the Statement's proposition (i.e. how confident they are that it is true or false). direct
evidenceDirection 0..1
Coding		 A term indicating the net direction of all evidence assessed against the Statement's proposition. direct
evidenceLevel 0..1
Coding		 A term indicating the overall strength of support for or against the Statement's proposition, as provided by all evidence evaluated. direct
evidenceScore 0..1
DataItem		 A quantitative score reflecting the overall strength of support for or against the Statement's proposition, as provided by all evidence evaluated. direct
conclusion 0..1
Coding		 A term that describes a final conclusion about the subject of a Statement's proposition, based on what the proposition claims, and confidence and evidence level and direction assessments. direct
hasEvidence 0..*
InformationEntity		 A piece of information that represents or contributes to an argument for or against the validity of the Proposition put forth in a Statement. direct
hasEvidenceLines 0..*
EvidenceLine		 A discrete, independent argument relevant to the validity of the Proposition put forth in the Statement, which is based on the interpretation of one or more pieces of information as evidence. direct
hasEvidenceOfTypes 0..*
Coding		 A term describing a type of evidence used to assess the validity of Statement's proposition (e.g. 'sequence similarity evidence', 'in vitro assay evidence'). direct
contributions 0..*
Contribution		 A specific contribution made by some Agent to the creation, modification, or validation of the information represented in the Information Entity. InformationEntity
dateAuthored 0..1
DateTime		 The date the information content expressed in this entity was generated. InformationEntity
specifiedBy 0..*
Method		 A particular plan specification that describes all or part of the process that led to creation of the reported information (e.g. a specific experimental protocol, analysis specification, cohort selection criteria, interpretation guideline, etc.). InformationEntity
derivedFrom 0..*
InformationEntity		 An information resource from which the Information Entity is derived, in whole or in part InformationEntity
reportedIn 0..*
Document		 A document in which the information content carried by the Information Entity is expressed InformationEntity
id 1..1
Identifier		 The logical identifier of the entity in the system of record, e.g. a UUID. This 'id' is unique within a given system. The identified entity may have a different 'id' in a different system. Entity
identifiers 0..*
Identifier		 A business identifier or accession number for the entity, typically as provided by an external system or authority, that is globally unique and persists across implementing systems. Entity
label 0..1
String		 A primary name for the Entity. Entity
urls 0..*
Url		 The URL/web address of a digital resource representing the entity, or providing information about it. Entity
xrefs 0..*
String		 Cross-references to database identifier(s) representing the same (or a closely related) entity or concept as the Entity. Entity
recordMetadata 0..1
RecordMetadata		 A reusable structure that encapsulates provenance metadata about the present record/data object (as opposed to provenance information about the real world entity this record/data object represents). Entity
type 1..1
Class		 The schema class that is instantiated by the data object. Must be the name of a class from the VA schema. Element
description 0..1
String		 A free text description of the Element. Element
extensions 0..*
Extension		 A key-value data structure that allows definition of custom fields to capture information not directly supported by the VA specification. Element

Comments

  • In the VA model, each assertion of knowledge about a variant is captured in a self-contained Statement object. Organization of variant knowledge into discrete Statement objects allows clear and precise tracking of the evidence and provenance that supports each.

The VA model allows Statemetns to simply put forth as true a specific proposition about the domain of discourse (e.g. that "BRCA2 c.8023A>G is pathogenic for Breast Cancer"), and/or describe the overall state of evidence and/or confidence surrounding a particular proposition (e.g. that "there is moderate evidence supporting the pathogenicity of BRCA2 c.8023A>G for Breast Cancer", or that "I have very high confidence in the truth of the proposition that BRCA2 c.8023A>G is pathogenic for Breast Cancer").

Aliases

  • Assertion; Claim

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/ga4gh-va-core-im

Mappings

Mapping Type Mapped Value
self vacoreim:Statement
native vacoreim:Statement

LinkML Source

Direct

name: Statement
description: An information entity expressing a declarative sentence that is either
  true or false.
title: Statement
comments:
- "In the VA model, each assertion of knowledge about a variant is captured in a self-contained\
  \ Statement object. Organization of variant knowledge into discrete Statement objects\
  \ allows clear and precise tracking of the evidence and provenance that supports\
  \ each. \n\nThe VA model allows Statemetns to simply put forth as true a specific\
  \ proposition about the domain of discourse (e.g. that \"BRCA2 c.8023A>G is pathogenic\
  \ for Breast Cancer\"), and/or describe the overall state of evidence and/or confidence\
  \ surrounding a particular proposition (e.g. that \"there is moderate evidence supporting\
  \ the pathogenicity of BRCA2 c.8023A>G for Breast Cancer\", or that \"I have very\
  \ high confidence in the truth of the proposition that BRCA2 c.8023A>G is pathogenic\
  \ for Breast Cancer\")."
from_schema: https://w3id.org/ga4gh-va-core-im
aliases:
- Assertion; Claim
is_a: InformationEntity
slots:
- subtype
- statementText
- proposition
- confidenceDirection
- confidenceLevel
- confidenceScore
- evidenceDirection
- evidenceLevel
- evidenceScore
- conclusion
- hasEvidence
- hasEvidenceLines
- hasEvidenceOfTypes
slot_usage:
  subtype:
    name: subtype
    description: A specific type of statement the Statement object represents (e.g.
      a 'Variant Pathogenicity Statement', or 'Therapeutic Response Evidence Level
      Statement')
    multivalued: false
    domain_of:
    - DataItem
    - DataSet
    - Document
    - Statement
    - StudyResult
    - EvidenceLine
    - Method
    - Activity
    - Agent
    - Proposition
    range: Coding
    required: false
  statementText:
    name: statementText
    description: A natural-language expression of what the Statement asserts to be
      true.
    comments:
    - This attribute captures what a Statement says as human readable free text. e.g.
      that "BRCA2 c.8023A>G is pathogenic for Breast Cancer", or that "there is moderate
      evidence supporting the pathogenicity of BRCA2 c.8023A>G for Breast Cancer".
      This optional attribute can be used instead of, or as a complement to, more
      structured representations of Statement semantics using the subject-predicate-object-qualifier
      pattern.
    multivalued: false
    domain_of:
    - Statement
    range: string
    required: false
  proposition:
    name: proposition
    description: 'A possible fact (Proposition) that the Statement is about.  A Statement
      may say any or all of the following about its Proposition: (1) simply report
      its as being true; (2) describe the author''s degree of confidence in the its
      truth; (3) report the author''s assessment of the level and direction of evidence
      backing it.'
    comments:
    - This attribute provides the option of encapsulating the structured semantics
      of the possible fact asserted or evaluated by a Statement in a separate 'Proposition'
      object.
    multivalued: false
    domain_of:
    - Statement
    range: Proposition
    required: false
  confidenceDirection:
    name: confidenceDirection
    description: A term indicating whether the confidenceLevel and/or confidenceScore
      values reflect confidence that the statement's proposition is true or false.
    comments:
    - Statements can report the asserting agent's confidence level that the target
      proposition is true, or false, using the confidenceDirection, confidenceLevel,
      and confidenceScore attributes.  e.g. if the propositionDirection is 'false'
      and confidenceLevel is 'high', the agent has high confidence that the proposition
      is false.  (Recommended values = 'true', 'false', 'uncertain')
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceLevel:
    name: confidenceLevel
    description: A term describing the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceLevel indicate the agent's confidence in the direction indicated -
      e.g. if the confidenceDirection is 'false' and confidenceLevel is 'high', the
      agent is very confident that the proposition is false.
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceScore:
    name: confidenceScore
    description: A quantitative score the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceScore provides a quantitative indication of the agent's confidence
      in the direction indicated - e.g. if the confidenceDirection is 'true' and confidenceScore
      is 9.8 out of 10, the agent has high confidence that the proposition is true.  A
      numeric confidenceScore may be provided instead of, or in addition to, qualitative
      confidenceLevel term -  where it provides quantitative rigor to the assessment.
    multivalued: false
    domain_of:
    - Statement
    range: DataItem
    required: false
  evidenceDirection:
    name: evidenceDirection
    description: A term indicating the net direction of all evidence assessed against
      the Statement's proposition.
    comments:
    - Statements can report that the evidence assessed generally supports its propostion
      (if it favors its validity), disputes its proposition (if it argues against
      its validity), or remains 'inconclusive' (if conficting or insufficient evidence
      exists to assert one direction or the other). (Recommended values = 'supports',
      'disputes', 'inconclusive'.)
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceLevel:
    name: evidenceLevel
    description: A term indicating the overall strength of support for or against
      the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - 'This attribute reports the asserting agent''s assessment of the overall strength
      of all examined evidence for the Statement''s proposition, in the direction
      reported by the evidenceDirection field. For example,  {"level": "strong", "direction":
      "supporting"} means that the collective evidnece ''strongly supports'' the Statement''s
      Proposition, while {"level": "strong", "direction": "disputing"} means that
      the collective evidence ''strongly disputes'' the Statement''s Proposition.

      The overall strength of evidence supporting or disputing a proposition is the
      predominant factor, but not the only factor, influencing the agent''s confidence
      that the proposition is true or false.'
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceScore:
    name: evidenceScore
    description: A quantitative score reflecting the overall strength of support for
      or against the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - This attribute serves the same purpose as evidenceLevel, but allows for numeric
      scores providing quantitative assessment of evidence strength. A numeric evidenceScore
      may be provided instead of, or in addition to, qualitative evidenceLevel term
      -  where it provides quantitative rigor to the assessment.
    multivalued: false
    domain_of:
    - Statement
    range: DataItem
    required: false
  conclusion:
    name: conclusion
    description: A term that describes a final conclusion about the subject of a Statement's
      proposition, based on what the proposition claims, and confidence and evidence
      level and direction assessments.
    comments:
    - "This value typically represents a common term of art used in the domain of\
      \ discourse - and can be provided to report of a statement's conclusion in user-friendly/familiar\
      \ terms. \nFor example, in a Statement declaring there to be 'definitive' evidence\
      \ 'supporting' the proposition that a variant causes a disease, the conclusion\
      \ term might be 'pathogenic'. And for a Statement declaring there to be 'probable'\
      \ evidence 'disputing' the proposition that a variant causes a disease, the\
      \ conclusion term might be 'likely benign'."
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  hasEvidence:
    name: hasEvidence
    description: A piece of information that represents or contributes to an argument
      for or against the validity of the Proposition put forth in a Statement.
    comments:
    - Evidence is any information that is interpreted in assessing the truth of  the
      proposition a Statement puts forth as true or false.  A piece of information
      only becomes evidence when it is interpreted in this way. Different types of
      information entities can be used and cited as evidence, including direct observation
      or measurement data, derived statistical calculations, data tables or figures
      in a publication, conclusions/findings from a particular study, or prior assertions
      of knowledge  that themselves are based on their own set of evidence.  This
      is a shortcut relation that links a Statement directly to a piece of evidnece
      supporting it, bypassing the EvidenceLine class - to be used data creators cannot
      or do not wich to create an Evidence Line object.
    multivalued: true
    domain_of:
    - Statement
    range: InformationEntity
    required: false
  hasEvidenceLines:
    name: hasEvidenceLines
    description: A discrete, independent argument relevant to the validity of the
      Proposition put forth in the Statement, which is based on the interpretation
      of one or more pieces of information as evidence.
    comments:
    - Evidence Lines result from the interpretation of one or more pieces of information
      to build an argument for or against a particular Proposition. These arguments
      have direction (supporting / disputing) and strength (e.g. strong, moderate,
      weak) relative to the Proposition they are evaluated against. For example, ExaC
      allele counts and frequency calculations for the BRCA2 c.8023A>G variant in
      different populations may be collectively assessed to provide an argument of
      moderate strength in support of a Proposition that the variant is pathogenicity
      for breast cancer.
    multivalued: true
    domain_of:
    - Statement
    range: EvidenceLine
    required: false
  hasEvidenceOfTypes:
    name: hasEvidenceOfTypes
    description: A term describing a type of evidence used to assess the validity
      of Statement's proposition (e.g. 'sequence similarity evidence', 'in vitro assay
      evidence').
    comments:
    - "This contrasts with separate attributes used to capture specific instances\
      \ of evidence information, such as a particular data item, study result, or\
      \ prior assertions, etc. \nThe VA-Spec recommends the use of terms from ontologies\
      \ such as the Evidence and Conclusion Ontology (ECO) to describe specific types\
      \ of evidence."
    multivalued: true
    domain_of:
    - Statement
    range: Coding
    required: false

Induced

name: Statement
description: An information entity expressing a declarative sentence that is either
  true or false.
title: Statement
comments:
- "In the VA model, each assertion of knowledge about a variant is captured in a self-contained\
  \ Statement object. Organization of variant knowledge into discrete Statement objects\
  \ allows clear and precise tracking of the evidence and provenance that supports\
  \ each. \n\nThe VA model allows Statemetns to simply put forth as true a specific\
  \ proposition about the domain of discourse (e.g. that \"BRCA2 c.8023A>G is pathogenic\
  \ for Breast Cancer\"), and/or describe the overall state of evidence and/or confidence\
  \ surrounding a particular proposition (e.g. that \"there is moderate evidence supporting\
  \ the pathogenicity of BRCA2 c.8023A>G for Breast Cancer\", or that \"I have very\
  \ high confidence in the truth of the proposition that BRCA2 c.8023A>G is pathogenic\
  \ for Breast Cancer\")."
from_schema: https://w3id.org/ga4gh-va-core-im
aliases:
- Assertion; Claim
is_a: InformationEntity
slot_usage:
  subtype:
    name: subtype
    description: A specific type of statement the Statement object represents (e.g.
      a 'Variant Pathogenicity Statement', or 'Therapeutic Response Evidence Level
      Statement')
    multivalued: false
    domain_of:
    - DataItem
    - DataSet
    - Document
    - Statement
    - StudyResult
    - EvidenceLine
    - Method
    - Activity
    - Agent
    - Proposition
    range: Coding
    required: false
  statementText:
    name: statementText
    description: A natural-language expression of what the Statement asserts to be
      true.
    comments:
    - This attribute captures what a Statement says as human readable free text. e.g.
      that "BRCA2 c.8023A>G is pathogenic for Breast Cancer", or that "there is moderate
      evidence supporting the pathogenicity of BRCA2 c.8023A>G for Breast Cancer".
      This optional attribute can be used instead of, or as a complement to, more
      structured representations of Statement semantics using the subject-predicate-object-qualifier
      pattern.
    multivalued: false
    domain_of:
    - Statement
    range: string
    required: false
  proposition:
    name: proposition
    description: 'A possible fact (Proposition) that the Statement is about.  A Statement
      may say any or all of the following about its Proposition: (1) simply report
      its as being true; (2) describe the author''s degree of confidence in the its
      truth; (3) report the author''s assessment of the level and direction of evidence
      backing it.'
    comments:
    - This attribute provides the option of encapsulating the structured semantics
      of the possible fact asserted or evaluated by a Statement in a separate 'Proposition'
      object.
    multivalued: false
    domain_of:
    - Statement
    range: Proposition
    required: false
  confidenceDirection:
    name: confidenceDirection
    description: A term indicating whether the confidenceLevel and/or confidenceScore
      values reflect confidence that the statement's proposition is true or false.
    comments:
    - Statements can report the asserting agent's confidence level that the target
      proposition is true, or false, using the confidenceDirection, confidenceLevel,
      and confidenceScore attributes.  e.g. if the propositionDirection is 'false'
      and confidenceLevel is 'high', the agent has high confidence that the proposition
      is false.  (Recommended values = 'true', 'false', 'uncertain')
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceLevel:
    name: confidenceLevel
    description: A term describing the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceLevel indicate the agent's confidence in the direction indicated -
      e.g. if the confidenceDirection is 'false' and confidenceLevel is 'high', the
      agent is very confident that the proposition is false.
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceScore:
    name: confidenceScore
    description: A quantitative score the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceScore provides a quantitative indication of the agent's confidence
      in the direction indicated - e.g. if the confidenceDirection is 'true' and confidenceScore
      is 9.8 out of 10, the agent has high confidence that the proposition is true.  A
      numeric confidenceScore may be provided instead of, or in addition to, qualitative
      confidenceLevel term -  where it provides quantitative rigor to the assessment.
    multivalued: false
    domain_of:
    - Statement
    range: DataItem
    required: false
  evidenceDirection:
    name: evidenceDirection
    description: A term indicating the net direction of all evidence assessed against
      the Statement's proposition.
    comments:
    - Statements can report that the evidence assessed generally supports its propostion
      (if it favors its validity), disputes its proposition (if it argues against
      its validity), or remains 'inconclusive' (if conficting or insufficient evidence
      exists to assert one direction or the other). (Recommended values = 'supports',
      'disputes', 'inconclusive'.)
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceLevel:
    name: evidenceLevel
    description: A term indicating the overall strength of support for or against
      the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - 'This attribute reports the asserting agent''s assessment of the overall strength
      of all examined evidence for the Statement''s proposition, in the direction
      reported by the evidenceDirection field. For example,  {"level": "strong", "direction":
      "supporting"} means that the collective evidnece ''strongly supports'' the Statement''s
      Proposition, while {"level": "strong", "direction": "disputing"} means that
      the collective evidence ''strongly disputes'' the Statement''s Proposition.

      The overall strength of evidence supporting or disputing a proposition is the
      predominant factor, but not the only factor, influencing the agent''s confidence
      that the proposition is true or false.'
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceScore:
    name: evidenceScore
    description: A quantitative score reflecting the overall strength of support for
      or against the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - This attribute serves the same purpose as evidenceLevel, but allows for numeric
      scores providing quantitative assessment of evidence strength. A numeric evidenceScore
      may be provided instead of, or in addition to, qualitative evidenceLevel term
      -  where it provides quantitative rigor to the assessment.
    multivalued: false
    domain_of:
    - Statement
    range: DataItem
    required: false
  conclusion:
    name: conclusion
    description: A term that describes a final conclusion about the subject of a Statement's
      proposition, based on what the proposition claims, and confidence and evidence
      level and direction assessments.
    comments:
    - "This value typically represents a common term of art used in the domain of\
      \ discourse - and can be provided to report of a statement's conclusion in user-friendly/familiar\
      \ terms. \nFor example, in a Statement declaring there to be 'definitive' evidence\
      \ 'supporting' the proposition that a variant causes a disease, the conclusion\
      \ term might be 'pathogenic'. And for a Statement declaring there to be 'probable'\
      \ evidence 'disputing' the proposition that a variant causes a disease, the\
      \ conclusion term might be 'likely benign'."
    multivalued: false
    domain_of:
    - Statement
    range: Coding
    required: false
  hasEvidence:
    name: hasEvidence
    description: A piece of information that represents or contributes to an argument
      for or against the validity of the Proposition put forth in a Statement.
    comments:
    - Evidence is any information that is interpreted in assessing the truth of  the
      proposition a Statement puts forth as true or false.  A piece of information
      only becomes evidence when it is interpreted in this way. Different types of
      information entities can be used and cited as evidence, including direct observation
      or measurement data, derived statistical calculations, data tables or figures
      in a publication, conclusions/findings from a particular study, or prior assertions
      of knowledge  that themselves are based on their own set of evidence.  This
      is a shortcut relation that links a Statement directly to a piece of evidnece
      supporting it, bypassing the EvidenceLine class - to be used data creators cannot
      or do not wich to create an Evidence Line object.
    multivalued: true
    domain_of:
    - Statement
    range: InformationEntity
    required: false
  hasEvidenceLines:
    name: hasEvidenceLines
    description: A discrete, independent argument relevant to the validity of the
      Proposition put forth in the Statement, which is based on the interpretation
      of one or more pieces of information as evidence.
    comments:
    - Evidence Lines result from the interpretation of one or more pieces of information
      to build an argument for or against a particular Proposition. These arguments
      have direction (supporting / disputing) and strength (e.g. strong, moderate,
      weak) relative to the Proposition they are evaluated against. For example, ExaC
      allele counts and frequency calculations for the BRCA2 c.8023A>G variant in
      different populations may be collectively assessed to provide an argument of
      moderate strength in support of a Proposition that the variant is pathogenicity
      for breast cancer.
    multivalued: true
    domain_of:
    - Statement
    range: EvidenceLine
    required: false
  hasEvidenceOfTypes:
    name: hasEvidenceOfTypes
    description: A term describing a type of evidence used to assess the validity
      of Statement's proposition (e.g. 'sequence similarity evidence', 'in vitro assay
      evidence').
    comments:
    - "This contrasts with separate attributes used to capture specific instances\
      \ of evidence information, such as a particular data item, study result, or\
      \ prior assertions, etc. \nThe VA-Spec recommends the use of terms from ontologies\
      \ such as the Evidence and Conclusion Ontology (ECO) to describe specific types\
      \ of evidence."
    multivalued: true
    domain_of:
    - Statement
    range: Coding
    required: false
attributes:
  subtype:
    name: subtype
    description: A specific type of statement the Statement object represents (e.g.
      a 'Variant Pathogenicity Statement', or 'Therapeutic Response Evidence Level
      Statement')
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: subtype
    owner: Statement
    domain_of:
    - DataItem
    - DataSet
    - Document
    - Statement
    - StudyResult
    - EvidenceLine
    - Method
    - Activity
    - Agent
    - Proposition
    range: Coding
    required: false
  statementText:
    name: statementText
    description: A natural-language expression of what the Statement asserts to be
      true.
    comments:
    - This attribute captures what a Statement says as human readable free text. e.g.
      that "BRCA2 c.8023A>G is pathogenic for Breast Cancer", or that "there is moderate
      evidence supporting the pathogenicity of BRCA2 c.8023A>G for Breast Cancer".
      This optional attribute can be used instead of, or as a complement to, more
      structured representations of Statement semantics using the subject-predicate-object-qualifier
      pattern.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: statementText
    owner: Statement
    domain_of:
    - Statement
    range: string
    required: false
  proposition:
    name: proposition
    description: 'A possible fact (Proposition) that the Statement is about.  A Statement
      may say any or all of the following about its Proposition: (1) simply report
      its as being true; (2) describe the author''s degree of confidence in the its
      truth; (3) report the author''s assessment of the level and direction of evidence
      backing it.'
    comments:
    - This attribute provides the option of encapsulating the structured semantics
      of the possible fact asserted or evaluated by a Statement in a separate 'Proposition'
      object.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: proposition
    owner: Statement
    domain_of:
    - Statement
    range: Proposition
    required: false
  confidenceDirection:
    name: confidenceDirection
    description: A term indicating whether the confidenceLevel and/or confidenceScore
      values reflect confidence that the statement's proposition is true or false.
    comments:
    - Statements can report the asserting agent's confidence level that the target
      proposition is true, or false, using the confidenceDirection, confidenceLevel,
      and confidenceScore attributes.  e.g. if the propositionDirection is 'false'
      and confidenceLevel is 'high', the agent has high confidence that the proposition
      is false.  (Recommended values = 'true', 'false', 'uncertain')
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: confidenceDirection
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceLevel:
    name: confidenceLevel
    description: A term describing the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceLevel indicate the agent's confidence in the direction indicated -
      e.g. if the confidenceDirection is 'false' and confidenceLevel is 'high', the
      agent is very confident that the proposition is false.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: confidenceLevel
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  confidenceScore:
    name: confidenceScore
    description: A quantitative score the asserting agent's level of confidence about
      the Statement's proposition (i.e. how confident they are that it is true or
      false).
    comments:
    - A Statement's proposition may ultimately be assessed by the agent to be true,
      false, or uncertain -  as indicated by the confidenceDirection attribute. The
      confidenceScore provides a quantitative indication of the agent's confidence
      in the direction indicated - e.g. if the confidenceDirection is 'true' and confidenceScore
      is 9.8 out of 10, the agent has high confidence that the proposition is true.  A
      numeric confidenceScore may be provided instead of, or in addition to, qualitative
      confidenceLevel term -  where it provides quantitative rigor to the assessment.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: confidenceScore
    owner: Statement
    domain_of:
    - Statement
    range: DataItem
    required: false
  evidenceDirection:
    name: evidenceDirection
    description: A term indicating the net direction of all evidence assessed against
      the Statement's proposition.
    comments:
    - Statements can report that the evidence assessed generally supports its propostion
      (if it favors its validity), disputes its proposition (if it argues against
      its validity), or remains 'inconclusive' (if conficting or insufficient evidence
      exists to assert one direction or the other). (Recommended values = 'supports',
      'disputes', 'inconclusive'.)
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: evidenceDirection
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceLevel:
    name: evidenceLevel
    description: A term indicating the overall strength of support for or against
      the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - 'This attribute reports the asserting agent''s assessment of the overall strength
      of all examined evidence for the Statement''s proposition, in the direction
      reported by the evidenceDirection field. For example,  {"level": "strong", "direction":
      "supporting"} means that the collective evidnece ''strongly supports'' the Statement''s
      Proposition, while {"level": "strong", "direction": "disputing"} means that
      the collective evidence ''strongly disputes'' the Statement''s Proposition.

      The overall strength of evidence supporting or disputing a proposition is the
      predominant factor, but not the only factor, influencing the agent''s confidence
      that the proposition is true or false.'
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: evidenceLevel
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  evidenceScore:
    name: evidenceScore
    description: A quantitative score reflecting the overall strength of support for
      or against the Statement's proposition, as provided by all evidence evaluated.
    comments:
    - This attribute serves the same purpose as evidenceLevel, but allows for numeric
      scores providing quantitative assessment of evidence strength. A numeric evidenceScore
      may be provided instead of, or in addition to, qualitative evidenceLevel term
      -  where it provides quantitative rigor to the assessment.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: evidenceScore
    owner: Statement
    domain_of:
    - Statement
    range: DataItem
    required: false
  conclusion:
    name: conclusion
    description: A term that describes a final conclusion about the subject of a Statement's
      proposition, based on what the proposition claims, and confidence and evidence
      level and direction assessments.
    comments:
    - "This value typically represents a common term of art used in the domain of\
      \ discourse - and can be provided to report of a statement's conclusion in user-friendly/familiar\
      \ terms. \nFor example, in a Statement declaring there to be 'definitive' evidence\
      \ 'supporting' the proposition that a variant causes a disease, the conclusion\
      \ term might be 'pathogenic'. And for a Statement declaring there to be 'probable'\
      \ evidence 'disputing' the proposition that a variant causes a disease, the\
      \ conclusion term might be 'likely benign'."
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: conclusion
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  hasEvidence:
    name: hasEvidence
    description: A piece of information that represents or contributes to an argument
      for or against the validity of the Proposition put forth in a Statement.
    comments:
    - Evidence is any information that is interpreted in assessing the truth of  the
      proposition a Statement puts forth as true or false.  A piece of information
      only becomes evidence when it is interpreted in this way. Different types of
      information entities can be used and cited as evidence, including direct observation
      or measurement data, derived statistical calculations, data tables or figures
      in a publication, conclusions/findings from a particular study, or prior assertions
      of knowledge  that themselves are based on their own set of evidence.  This
      is a shortcut relation that links a Statement directly to a piece of evidnece
      supporting it, bypassing the EvidenceLine class - to be used data creators cannot
      or do not wich to create an Evidence Line object.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: hasEvidence
    owner: Statement
    domain_of:
    - Statement
    range: InformationEntity
    required: false
  hasEvidenceLines:
    name: hasEvidenceLines
    description: A discrete, independent argument relevant to the validity of the
      Proposition put forth in the Statement, which is based on the interpretation
      of one or more pieces of information as evidence.
    comments:
    - Evidence Lines result from the interpretation of one or more pieces of information
      to build an argument for or against a particular Proposition. These arguments
      have direction (supporting / disputing) and strength (e.g. strong, moderate,
      weak) relative to the Proposition they are evaluated against. For example, ExaC
      allele counts and frequency calculations for the BRCA2 c.8023A>G variant in
      different populations may be collectively assessed to provide an argument of
      moderate strength in support of a Proposition that the variant is pathogenicity
      for breast cancer.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: hasEvidenceLines
    owner: Statement
    domain_of:
    - Statement
    range: EvidenceLine
    required: false
  hasEvidenceOfTypes:
    name: hasEvidenceOfTypes
    description: A term describing a type of evidence used to assess the validity
      of Statement's proposition (e.g. 'sequence similarity evidence', 'in vitro assay
      evidence').
    comments:
    - "This contrasts with separate attributes used to capture specific instances\
      \ of evidence information, such as a particular data item, study result, or\
      \ prior assertions, etc. \nThe VA-Spec recommends the use of terms from ontologies\
      \ such as the Evidence and Conclusion Ontology (ECO) to describe specific types\
      \ of evidence."
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: hasEvidenceOfTypes
    owner: Statement
    domain_of:
    - Statement
    range: Coding
    required: false
  contributions:
    name: contributions
    description: A specific contribution made by some Agent to the creation, modification,
      or validation of the information represented in the Information Entity.
    comments:
    - This attribute points to a Contribution object, which holds a structured description
      of the actions taken by a particular agent in contributing to an Information
      Entity.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: contributions
    owner: Statement
    domain_of:
    - InformationEntity
    - RecordMetadata
    range: Contribution
    required: false
  dateAuthored:
    name: dateAuthored
    description: The date the information content expressed in this entity was generated.
    comments:
    - We use the term 'authored' to refer to the generation of information in the
      abstract - i.e. the information content expressed in a Statement, not a concrete
      encoding of it in a specific language or format.  The 'dateAuthored' attribute
      captures when this abstract information content was first created.  Information
      about when a particular concrete encoding of this information was created (e.g.
      as a VA-based json object) would live in a RecordMetadata object attached to
      the Information Entity).
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: dateAuthored
    owner: Statement
    domain_of:
    - InformationEntity
    range: DateTime
    required: false
  specifiedBy:
    name: specifiedBy
    description: A particular plan specification that describes all or part of the
      process that led to creation of the reported information (e.g. a specific experimental
      protocol, analysis specification, cohort selection criteria, interpretation
      guideline, etc.).
    comments:
    - 'This field captures specific instances of specifications / methods (vs the
      ''methodTypes'' attribute which captures types of methods applied).

      In various domains and communities, such specifications may be called ''protocols'',
      ''guidelines'', ''methods'', ''rule sets'', etc.'
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: specifiedBy
    owner: Statement
    domain_of:
    - InformationEntity
    - Activity
    range: Method
    required: false
  derivedFrom:
    name: derivedFrom
    description: An information resource from which the Information Entity is derived,
      in whole or in part
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: derivedFrom
    owner: Statement
    domain_of:
    - InformationEntity
    - StudyResult
    - RecordMetadata
    range: InformationEntity
    required: false
  reportedIn:
    name: reportedIn
    description: A document in which the information content carried by the Information
      Entity is expressed
    comments:
    - "This attribute is used specifically to reference documents/publications where\
      \ the Information Entity is expressed or reported.  For a Statement, this might\
      \ be a publication where the authors express the statement in text.  For a Data\
      \ Item, this might be a publication with a table or figure that reports the\
      \ value of the  data.  \nNote that the VA-Spec provide separate attributes for\
      \ describing different types of 'references' from an Information Entity to a\
      \ Document (e.g. hasEvidenceFromSource is used by a Statement to reference a\
      \ Document that provided evidence for the knowldege the Statement expresses."
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: reportedIn
    owner: Statement
    domain_of:
    - InformationEntity
    range: Document
    required: false
  id:
    name: id
    description: The logical identifier of the entity in the system of record, e.g.
      a UUID.  This 'id' is unique within a given system. The identified entity may
      have a different 'id' in a different system.
    comments:
    - FHIR naming conventions are followed here, where an 'id' field holds logical
      identifiers which are unique only within a given system, and an 'identifier'
      field holds business identifiers, which are globally unique and used to connect
      entities and share content across systems.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: id
    owner: Statement
    domain_of:
    - Entity
    range: Identifier
    required: true
  identifiers:
    name: identifiers
    description: A business identifier or accession number for the entity, typically
      as provided by an external system or authority, that is globally unique and
      persists across implementing systems.
    comments:
    - FHIR naming conventions are followed here, where an 'id' field holds logical
      identifiers which are unique only within a given system, and an 'identifier'
      field holds business identifiers, which are globally unique and used to connect
      entities and share content across systems.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: identifiers
    owner: Statement
    domain_of:
    - Entity
    range: Identifier
    required: false
  label:
    name: label
    description: A primary name for the Entity.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: label
    owner: Statement
    domain_of:
    - Entity
    - Coding
    range: string
    required: false
  urls:
    name: urls
    description: The URL/web address of a digital resource representing the entity,
      or providing information about it.
    comments:
    - This attribute is meant to point directly to locations on the web where more
      information about the Entity can be found.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: urls
    owner: Statement
    domain_of:
    - Entity
    range: Url
    required: false
  xrefs:
    name: xrefs
    description: Cross-references to database identifier(s) representing the same
      (or a closely related) entity or concept as the Entity.
    comments:
    - Preferred values for this field are CURIEs or URLs for database records - so
      the system that provisioned the identifier is clear.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: xrefs
    owner: Statement
    domain_of:
    - Entity
    range: string
    required: false
  recordMetadata:
    name: recordMetadata
    description: A reusable structure that encapsulates provenance metadata about
      the present record/data object  (as opposed to provenance information about
      the real world entity this record/data object represents).
    comments:
    - Record-level metadata applies to a specific concrete encoding/serialization
      of information (e.g as a record in a specific knowlegebase, or an online digital
      resource). A RecordMetadata object can capture when, how, and by whom a specific
      record was generated or modified; what upstream resources it was derived/retrieved
      from; and record-level administrative information such as versioning and system
      / lifecycle status.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: recordMetadata
    owner: Statement
    domain_of:
    - Entity
    range: RecordMetadata
    required: false
  type:
    name: type
    description: The schema class that is instantiated by the data object.  Must be
      the name of a class from the VA schema.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: type
    owner: Statement
    domain_of:
    - Element
    range: Class
    required: true
  description:
    name: description
    description: A free text description of the Element.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: false
    alias: description
    owner: Statement
    domain_of:
    - Element
    - Extension
    range: string
    required: false
  extensions:
    name: extensions
    description: A key-value data structure that allows definition of custom fields
      to capture information not directly supported by the VA specification.
    comments:
    - The VA-Spec provides  implementers the ability to extend any model elements
      with new attributes using this flexible Extension element.
    from_schema: https://w3id.org/ga4gh-va-core-im
    rank: 1000
    multivalued: true
    alias: extensions
    owner: Statement
    domain_of:
    - Element
    range: Extension
    required: false